Sodium Hydroxide → HCID 19001361, compound

Participants

Reaction Steps

220 mg of the product of Example 1 were introduced into 6.6 ml of ethanol and 0.6 ml of sodium hydroxide and after stirring at ambient temperature for 3 days and followed by evaporation to dryness under reduced pressure at a temperature below 40° C., the residue was dissolved in 2 ml of water and neutralized by the addition of approximately 0.6 ml of 2N hydrochloric acid. After separating and washing with water, 160 mg of product were obtained which was crystallized from 5 ml of hot isopropanol with 5 ml of water added to it. After 24 hours at 0°+5° C., 90 mg were separated and crystallized from 9 ml of ethyl acetate at reflux. After standing at rest for 24 hours, separation took place to obtain 46 mg of the expected product melting at approx. 205° C.

Provenance & Evidence