Trifluoroacetic acid → HCID 88435369, compound

Participants

Reaction Steps

160 mg of the product of Example 3 were introduced into 4 ml of methylene chloride and 1 ml of trifluoroacetic acid and after the mixture was stirred at ambient temperature for 2 hours 30 minutes, it was diluted with 20 ml of methylene chloride, washed twice with 10 ml of water, extracted again with 20 ml of methylene chloride and evaporated to dryness under reduced pressure to obtain 140 mg of product which was crystallized from 1 ml of methylene chloride with 3 ml of isopropyl ether added to it. After standing at rest for approximately 16 hours, separation took place to obtain 77 mg of the expected product melting at 130° C.

Provenance & Evidence