Sodium Hydroxide → HCID 44210622, compound

Participants

Reaction Steps

175 mg of the product of Example 7 were introduced into 1.75 ml of dioxane and 1.6 ml of N sodium hydroxide and after stirring at ambient temperature for 3 days, followed by dilution with 10 ml of water, neutralization with 1.6 ml of 1N hydrochloric acid, extraction 5 times with 10 ml of methylene chloride and evaporation to dryness under reduced pressure, the residue was taken up in 2 ml of hexane, stirred for 1 hour and separated to obtain 152 mg of the expected product melting at approx 100°-110° C.

Provenance & Evidence