Water → Trifluoroacetic acid

Participants

Reaction Steps

To a solution of 3-((2R,4R)-1-(tert-butoxycarbonyl)-4-{[tert-butyl(dimethyl)silyl]oxy}-pyrrolidin-2-yl)propanoic acid (5.1 g, 13.65 mmol) in dichloromethane (100 ml) at 0° C. were added trifluoroacetic acid (14 ml) and water (3 ml). The reaction mixture was allowed to warm up and stirred overnight. The reaction mixture was concentrated in vacuo to afford 3-[(2R,4R)-4-hydroxypyrrolidin-2-yl]propanoic acid as TFA salt (3.74 g). Yield: 100%

Provenance & Evidence