HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Nitro-4-trifluoromethylanisole → 2-Methoxy-5-(trifluoromethyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Nitro-4-trifluoromethylanisole | HCID 96748 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Methoxy-5-(trifluoromethyl)aniline | HCID 600637 | — |
Reaction Steps
2-Methoxy-5-trifluoromethyl-nitrobenzene (283 mmol, 62,67 g) suspended in ethanol (500 ml) is hydrogenated over palladium on carbon 5% (1.7 g) and the reaction mixture is filtered through celite. The filtrate is concentrated in vacuo yielding the title compound as light grey crystals M.p. 61° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05475015 |
| Source dataset | uspto-grants-1995_12 |
| ORD ID | ord-3acc2883e333471e9105a157b702d3ba |
| Source note | uspto-grants-1995_12 |