Water → HCID 19001528, compound

Participants

Reaction Steps

9 ml of benzoyl chloride was added dropwise to a solution of 15 g of the 6-nitro-2-hydroxymethylbenzothiazole obtained in the Preparation Example 2 and 11 ml of triethylamine in tetrahydrofuran at 10° C. The reaction mixture was stirred at room temperature for 1 h and water was added thereto. After extraction with ethyl acetate, the extract was dried over sodium sulfate and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (solvent: dichloromethanol/methanol) to give 10 g of the titled compound.

Provenance & Evidence