4-Toluenesulfonyl chloride → HCID 19001524, compound

Participants

Reaction Conditions

Reaction Steps

75 g of the N-(6-nitrobenzothiazol-2-yl)isonipecotamide obtained in the Preparation Example 12 was dissolved in 700 ml of dimethylformamide. 50 g of p-toluenesulfonoyl chloride was added to the solution and the mixture was heated at 110° C. for 20 min, poured into ice/water and neutralized with sodium hydroxide. The formed precipitates were recovered by filtration, washed with water and then with ether, and dried to give 60 g of the titled compound.

Provenance & Evidence