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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 225968Generated: October 28, 2026

Morpholine → biphenyl-4-ylcarbonyl-5-(2-morpholin-4yl-2-oxoethyl) pyrrolidin-3-one O-methyloxime

https://huagongshe.com/reaction/225968

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMorpholineHCID 8083—
Reactant[(2S,4EZ)-1-(biphenyl-4-ylcarbonyl)-4-(methoxyimino)pyrrolidin-2-yl] acetic acidHCID 131727525—
Productbiphenyl-4-ylcarbonyl-5-(2-morpholin-4yl-2-oxoethyl) pyrrolidin-3-one O-methyloximeHCID 5775401598%

Reaction Steps

The same method as employed in the preparation of Example 7, but starting from [(2S,4EZ)-1-(biphenyl-4-ylcarbonyl)-4-(methoxyimino)pyrrolidin-2-yl]acetic acid (Intermediate 7) and morpholine, gave the title compound. Yield: 98%. HPLC purity: 100%

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07557136B2
Source datasetuspto-grants-2009_07
ORD IDord-4c7214504eeb4860acabb139b626737b
Source noteuspto-grants-2009_07