2-Amino-3-(4-fluorobenzoyl)-alpha-(n-propylthio)-phenylacetamide → 2-Amino-3-(4-fluorobenzoyl)-phenylacetamide

Participants

Reaction Steps

A solution of 24.2 g (0.07mole) of 2-amino-3-(4-fluorobenzoyl)-α-(n-propylthio)phenylacetamide in 300 mL of tetrahydrofuran was treated with an excess of wet Raney nickel (washed three times with water and three times with tetrahydrofuran). The mixture was stirred for 1 h and filtered. The filtrate was concentrated under reduced pressure and the residue was crystallized from 95% ethanol to afford 14.8 g (78%) of yellow needles melting at 184°-186° C.

Provenance & Evidence