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Dimethylformamide → HCID 178468747、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Chloro-1-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethanone | HCID 14726533 | — |
| 反応物 | 4-Amidinobenzoic acid ethyl ester hydrochloride | HCID 67790291 | — |
| 生成物 | HCID 178468747 | HCID 178468747 | — |
反応手順
2.6 g (10 millmoles) of 6-chloroacetyl-1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalene (for preparation see Example 28), 2.1 g (10 millimoles) of 4-carbethoxybenzamidinium chloride and 5 g of potassium carbonate in 100 ml of dimethylformamide were refluxed for 1 hour. After cooling, the mixture was poured onto water and stirred for 10 minutes, and the precipitate formed was filtered off under suction. Purification by column chromatography (silica gel; 9:1 n-heptane/ethyl acetate) gave 0.3 g of the title compound of melting point 186°-188° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05475017 |
| 出典データセット | uspto-grants-1995_12 |
| ORD ID | ord-3613daa91ad34be8b0f707b288a75894 |
| 出典メモ | uspto-grants-1995_12 |