HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Tolyl isocyanate → tert-butyl 2-{N-(2-fluorophenyl)-2-[3-(3-methylphenyl)ureido]-acetamido}acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Tolyl isocyanate | HCID 69303 | — |
| Reactant | Glycine, N-(2-fluorophenyl)-N-glycyl-, 1,1-dimethylethyl ester | HCID 19001954 | — |
| Product | tert-butyl 2-{N-(2-fluorophenyl)-2-[3-(3-methylphenyl)ureido]-acetamido}acetate | HCID 19002048 | 47.6% |
Reaction Steps
Using a procedure similar to that described in Example 1, but starting with tert-butyl 2-[2-amino-N-(2-fluorophenyl)acetamido]acetate (2.5 g) and 3-methylphenyl isocyanate (1.2 g), and after recrystallisation in diisopropyl ether, tert-butyl 2-{N-(2-fluorophenyl)-2-[3-(3-methylphenyl)ureido]-acetamido}acetate (1.75 g), m.p. 148° C., is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05475106 |
| Source dataset | uspto-grants-1995_12 |
| ORD ID | ord-384364f24bde49d8a24d29d63ecab195 |
| Source note | uspto-grants-1995_12 |