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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2259947Generated: November 1, 2026

m-Tolyl isocyanate → tert-butyl 2-{2-[3-(3-methylphenyl)ureido]-N-(3-trifluoromethoxyphenyl)acetamido}acetate

https://huagongshe.com/reaction/2259947

Reaction equation

Participants

RoleNameHCIDCharge
Reactantm-Tolyl isocyanateHCID 69303—
ReactantHCID 19001931HCID 19001931—
Producttert-butyl 2-{2-[3-(3-methylphenyl)ureido]-N-(3-trifluoromethoxyphenyl)acetamido}acetateHCID 1900204937.2%

Reaction Steps

Using a procedure similar to that described in Example 1, but starting with tert-butyl 2-[2-amino-N-(3-trifluoromethoxyphenyl)acetamido]acetate (3.4 g) and 3-methylphenyl isocyanate (1.4 g), and after recrystallisation in diisopropyl ether, tert-butyl 2-{2-[3-(3-methylphenyl)ureido]-N-(3-trifluoromethoxyphenyl)acetamido}acetate (1.75 g), m.p. 125° C., is obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05475106
Source datasetuspto-grants-1995_12
ORD IDord-4ebfa5cdcb3a4e0eacb0bbe39ad32e41
Source noteuspto-grants-1995_12