Dimethylformamide → HCID 57752942, compound

Participants

Reaction Conditions

Reaction Steps

To N,N-dimethyl formamide (9 mL) under nitrogen at room temperature was added POCl3 (3mL) and the resulting slurry was stirred for 5 min. 5,7-Dichloro-6-methylpyrazolo[1,5-a]pyrimidine (5 g) was slowly added and resulting thick mixture was heated at 70° C. for 3 h. The mixture was poured onto ice and basified with sodium hydroxide (5 g). The residue was filtered and the dried precipitate chromatographed on silica gel (eluting with CH2Cl2→20% ethyl acetate/CH2Cl2) to give the title compound (3.74 g); mp 137-139° C.

Provenance & Evidence