m-Tolyl isocyanate → tert-butyl 2-{N-(2-ethoxycarbonylphenyl)-2-[3-(3-methylphenyl)ureido]acetamido}acetate

Participants

Reaction Steps

Using a procedure similar to that described in Example 1, but starting with tert-butyl 2-[2-amino-N-(2-ethoxycarbonylphenyl)acetamido]acetate (3.6 g) and 3-methylphenyl isocyanate (1.42 g), and after recrystallisation in diisopropyl ether, tert-butyl 2-{N-(2-ethoxycarbonylphenyl)-2-[3-(3-methylphenyl)ureido]acetamido}acetate (1.35 g), m.p. 142° C., is obtained.

Provenance & Evidence