HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Tolyl isocyanate → tert-butyl 2-{N-(2-methoxyphenyl)-2-[3-(3-methylphenyl)ureido]acetamido}acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Tolyl isocyanate | HCID 69303 | — |
| Reactant | Glycine, N-glycyl-N-(2-methoxyphenyl)-, 1,1-dimethylethyl ester | HCID 19001958 | — |
| Product | tert-butyl 2-{N-(2-methoxyphenyl)-2-[3-(3-methylphenyl)ureido]acetamido}acetate | HCID 19002039 | 49.2% |
Reaction Steps
Using a procedure similar to that described in Example 11, but starting with tert-butyl 2-[2-amino-N-(2-methoxyphenyl)acetamido]acetate (4.2 g) and 3-methylphenyl isocyanate (1.9 g), and after recrystallisation in ethyl acetate, tert-butyl 2-{N-(2-methoxyphenyl)-2-[3-(3-methylphenyl)ureido]acetamido}acetate (3 g), m.p. 171° C., is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05475106 |
| Source dataset | uspto-grants-1995_12 |
| ORD ID | ord-309274d1db54497582a445fed4d0d04b |
| Source note | uspto-grants-1995_12 |