HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → tert-butyl 2-{N-(2,3-dichlorophenyl)-2-[3-(3-methylphenyl)ureido]acetamido}acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-{[(3-Methylphenyl)carbamoyl]amino}acetic acid | HCID 14996960 | — |
| Reactant | Tert-butyl 2-[(2,3-dichlorophenyl)amino]acetate | HCID 19002030 | — |
| Product | tert-butyl 2-{N-(2,3-dichlorophenyl)-2-[3-(3-methylphenyl)ureido]acetamido}acetate | HCID 19002046 | 12.9% |
Reaction Steps
Using a procedure similar to that described in Example 17, but starting with 2-[3-(3-methylphenyl)ureido]acetic acid (1.04 g), tert-butyl 2-[(2,3-dichlorophenyl)amino]acetate (1.4 g) and sulphinyl chloride (0.6 g), and after recrystallisation in acetonitrile, tert-butyl 2-{N-(2,3-dichlorophenyl)-2-[3 -(3-methylphenyl)ureido]acetamido}acetate (0.3 g), m.p. 135° C., is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05475106 |
| Source dataset | uspto-grants-1995_12 |
| ORD ID | ord-784f988426024c20a663285730dcb9d7 |
| Source note | uspto-grants-1995_12 |