Ammonium Chloride → HCID 57752947, compound

Participants

Reaction Steps

To 5,7-dichloro-6-methylpyrazolo[1,5-a]pyrimidine-3-carbaldehyde (200 mg) in ethanol (20 mL) was added sodium borohydride (70 mg) and the reaction mixture was stirred at room temperature for 15 min. Saturated aqueous NH4Cl (1 mL) was added and the reaction mixture was stirred for a further 10 min then the solvent was removed under reduced pressure. Water and ethyl acetate were added and the product was extracted with ethyl acetate (3×). The combined organic phase was washed (water, saturated aqueous NaCl) and dried (MgSO4) to give the title compound (150 mg); 1H-NMR (400 MHz, CDCl3) d(ppm): 8.22 (1H, s, 2-H), 4.90 (1H, s, CH2OH).

Provenance & Evidence