3-Aminobenzyl alcohol → HCID 15670993, compound

HRID 2259970Notes

Reaction equation

HRID 2259970 reaction equation
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][CH:9]=1)[NH2:6].[CH3:10][O:11][C:12]1[CH:13]=[C:14]([N:18]([CH2:25][C:26]([N:28]([CH3:35])[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[O:27])[C:19](=[O:24])[CH2:20][N:21]=[C:22]=[O:23])[CH:15]=[CH:16][CH:17]=1>>[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([NH:6][C:22](=[O:23])[NH:21][CH2:20][C:19]([N:18]([CH2:25][C:26]([N:28]([CH3:35])[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[O:27])[C:14]2[CH:15]=[CH:16][CH:17]=[C:12]([O:11][CH3:10])[CH:13]=2)=[O:24])[CH:7]=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 802933-Aminobenzyl alcoholHCID 15670983HCID 15670983, compound

Product 1

HCID 15670993HCID 15670993, compoundYield 61.1%

Procedure

Using a procedure similar to that described in Example 31, but starting with 3-(hydroxymethyl)aniline (1.1 g) and 2-[N-(3-methoxyphenyl)isocyanatoacetamido]-N-methyl-N-phenylacetamide (3.2 g), and after recrystallisation in ethyl acetate, 2-[2-{3-[3-(hydroxymethyl)phenyl]ureido}-N-(3-methoxyphenyl)acetamido]-N-methyl-N-phenylacetamide (2.6 g), m.p. 142° C., is obtained.

Workup

  1. customafter recrystallisation in ethyl acetate

Sources & evidence

ORD record
ord-9b838a090bdf48f2a085aee4a4c59baf
Source dataset
uspto-grants-1995_12
Patent number
US05475106

Reaction notes

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