Hydrochloric Acid → HCID 178466657, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred suspension of ethyl 5-({trans-4-[(tert-butoxy)carbonylamino]cyclohexyl}amino)-7-[(tert-butoxy)-N-(4-ethoxyphenyl)carbonylamino]-6-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate (5.55 g) in 2-propanol (136 mL) was added 2 mol/L aqueous NaOH (34 mL). The resulting mixture was stirred at 50° C. for 40 h, and then at 80° C. for 4 h. The mixture was acidified (pH 4) with 1 mol/L aqueous HCl and concentrated in vacuo. The residue was suspended in water (150 mL) and slowly stirred for 1 h. The precipitate was filtered and dried in vacuo to give the title compound (5.35 g, yield 78%) as a white solid. The 1H-NMR and ESI/MS data for this compound are shown below.

Provenance & Evidence