Methyl iodide → HCID 86749153, compound

Participants

Reaction Steps

Ethyl (E)-2-[2-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethylnaphthalen-2-yl)propen-1-yl]-5-imidazolecarboxylate (Compound 5, 25 mg, 0.066 mmol) was dissolved in acetone (3 mL) at room temperature and treated with methyl iodide (0.025 mL) and K2CO3 (100 mg). The suspension was stirred for 24 hours, filtered through Celite and concentrated under reduced pressure. The residue was treated with water (5 mL) and the organic material was extracted with ethyl acetate, washed with brine, dried (MgSO4) and concentrated in vacuo. The residue was purified by flash chromatography on silica gel (hexanes/ethyl acetate=5:1) to give the title compound as a light yellow solid (14 mg, 54%).

Provenance & Evidence