HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 178430600, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 3-Pyridinylboronic acid | HCID 2734378 | — |
| Reactant | HCID 178430601 | HCID 178430601 | — |
| Product | HCID 178430600 | HCID 178430600 | 15% |
Reaction Steps
The title compound and Boc protected intermediate were synthesised in the same manner as above using N-{5-[(trans-4-aminocyclohexyl)amino]-6-methyl(pyrazolo[1,5-a]pyrimidin-7-yl)}(tert-butoxy)-N-(3-iodophenyl)carboxamide, pyridine-3-boronic acid, Na2CO3 palladium (II) acetate and triphenylphosphine. The title compound (6.1 mg, 15% yield as 3 trifluoroacetic acids salt) was obtained. The HPLC retention time and ESI/MS data for this compound are shown below.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557110B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-38c7412816364a3889f87c36d0746461 |
| Source note | uspto-grants-2009_07 |