反应详情

Compound 20 (1.09 g, 2.03 mmol) in anhydrous MeOH (50 mL) was hydrogenated over 10% Pd.C (436 mg) under H2 (45 psi) in a Parr apparatus. The vessel was evacuated and replenished with H2 at approximately 30 minute intervals. After 4 hours, the mixture was removed, filtered through celite and solvent removed under reduced pressure, yielding crude 21 (813 mg). Purification by silica gel chromatography afforded pure 21 (694 mg, 85%).

1. customThe vessel was evacuated
2. waitAfter 4 hours
3. customthe mixture was removed
4. filtrationfiltered through celite and solvent
5. customremoved under reduced pressure