Hydrochloric Acid → HCID 10857704, compound

Participants

Reaction Steps

Ethyl 2-bromo-4-nitrobenzoate (46 g; 0.17 mole), ethanol (250 ml), iron powder (28 g; 0.5 mole) and concentrated hydrochloric acid (20 ml) are successively introduced into a 1 liter flask. The mixture is taken to reflux temperature for four hours. After cooling, the reaction mixture is treated with a saturated solution of sodium bicarbonate (500 ml) and extracted with ethyl acetate (5×300 ml). After drying over magnesium sulphate, filtration and evaporation, ethyl 4-amino-2-bromobenzoate (35.2 g; yield: 86%) is isolated, m.p. 93° C. (compound no. 254).

Provenance & Evidence