Ethanimidic acid, ethyl ester, hydrochloride (1:1) → HCID 178439387, compound

HRID 2260040Notes

Reaction equation

HRID 2260040 reaction equation
[NH2:1][C:2]1[CH:6]=[C:5]([CH2:7][CH2:8][CH3:9])[NH:4][N:3]=1.[ClH:10].[C:11](=[NH:16])(OCC)[CH3:12]>C(#N)C>[ClH:10].[CH2:7]([C:5]1[NH:4][N:3]=[C:2]([NH:1][C:11](=[NH:16])[CH3:12])[CH:6]=1)[CH2:8][CH3:9]

Participants

4

Reactant 2

HCID 2724290Ethanimidic acid, ethyl ester, hydrochloride (1:1)HCID 222656845-Propyl-1H-pyrazol-3-amine

Product 1

HCID 178439387HCID 178439387, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A 11.5 g portion of 3-amino-5-propyl-1H-pyrazole was dissolved in 60 ml of acetonitrile, and 12.8 g of ethyl acetimidate hydrochloride was added to the above solution with cooling on an ice bath. The resulting mixture was stirred for 1 hour at the same temperature and then overnight at room temperature.

Workup

  1. temperaturewith cooling on an ice bath
  2. customovernight
  3. customat room temperature

Sources & evidence

ORD record
ord-064c52bb5b48440fbb925e53e1ddedd9
Source dataset
uspto-grants-1995_12
Patent number
US05475114

Reaction notes

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