HCID 19002173, compound → HCID 178438424, compound

HRID 2260046Notes

Reaction equation

HRID 2260046 reaction equation
C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[C:19]3[CH:24]=[CH:23][C:22]([CH2:25][N:26]4[N:30]5[N:31]=[C:32]([CH3:34])[N:33]=[C:29]5[C:28]([CH2:35][C:36]5[CH:41]=[CH:40][C:39]([C:42]6[CH:47]=[CH:46][CH:45]=[CH:44][C:43]=6[C:48]6[N:52](C(C7C=CC=CC=7)(C7C=CC=CC=7)C7C=CC=CC=7)[N:51]=[N:50][N:49]=6)=[CH:38][CH:37]=5)=[C:27]4[CH2:72][CH2:73][CH3:74])=[CH:21][CH:20]=3)=[N:11][N:10]=[N:9]2)C=CC=CC=1>C1(C)C=CC=CC=1>[NH:11]1[C:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]2[CH:20]=[CH:21][C:22]([CH2:25][N:26]3[N:30]4[N:31]=[C:32]([CH3:34])[N:33]=[C:29]4[C:28]([CH2:35][C:36]4[CH:41]=[CH:40][C:39]([C:42]5[CH:47]=[CH:46][CH:45]=[CH:44][C:43]=5[C:48]5[NH:49][N:50]=[N:51][N:52]=5)=[CH:38][CH:37]=4)=[C:27]3[CH2:72][CH2:73][CH3:74])=[CH:23][CH:24]=2)=[N:8][N:9]=[N:10]1

Participants

3

Reactant 1

HCID 19002173HCID 19002173, compound2×

Product 1

HCID 178438424HCID 178438424, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A 342 mg portion of 5,7-bis[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-2-methyl-6-propyl-5H-pyrazolo[1,5-b][1,2,4]triazole (compound 1a) was treated in the same manner as described in Example 12, the resulting residue was mixed with toluene and heated under reflux and then the solution was cooled spontaneously to collect the thus formed precipitate by filtration, thereby giving 182 mg of 5,7-bis[[2'-(tetrazol-5-yl)biphenyl-4-yl]methyl]-2-methyl- 6-propyl-5H-pyrazolo[1,5-b][1,2,4]triazole in the form of colorless amorphous solid.

Workup

  1. temperatureheated
  2. temperatureunder reflux
  3. temperaturethe solution was cooled spontaneously
  4. customto collect the thus formed precipitate
  5. filtrationby filtration

Sources & evidence

ORD record
ord-4e6930061ed548c996fb161439b3cf64
Source dataset
uspto-grants-1995_12
Patent number
US05475114

Reaction notes

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