反应详情

Hexanoyl chloride (2.65g, 19.7 mmoles) was added dropwise to a reactor containing N-(2,3-dihydroxypropyl)-hexadecylamine (2.65g, 19.7 mmoles)in 8 mL of chloroform. The reaction was stirred for 16 hours at room temperature. When the reaction was completed, the mixture was concentrated, ethanol and water was added, and the pH of the reaction was adjusted to 14. This mixture was extracted with chloroform, and organic layer was collected and concentrated. The crude sample was purified on silica column chromatography to give 1.56 g of product.

1. concentrationthe mixture was concentrated
2. additionethanol and water was added
3. extractionThis mixture was extracted with chloroform, and organic layer
4. customwas collected
5. concentrationconcentrated
6. customThe crude sample was purified on silica column chromatography