Hexadecylamine → 3-(Hexadecylamino)propane-1,2-diol

Participants

Reaction Steps

Hexadecylamine (767 g, 3.17 mole) was dissolved in absolute ethanol. Glycidol (112 g, 1.58 mole) was added to the amine dropwise. The reaction was refluxed under nitrogen for 16 hours and then stirred at room temperature overnight. A white solid was obtained and filtered. The solid was washed with ether, filtered and recrystallized from hot ethanol. (yield 245 g).

Provenance & Evidence