Potassium Hydroxide → N-(2,3-dihydroxypropyl)-N-hexadecyl-2-hydroxyoctanamide

HRID 2260091ノート

反応式

HRID 2260091 の反応式
[OH:1][CH:2]([CH2:21][OH:22])[CH2:3][NH:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20].[OH-].[K+].C[O:26][C:27](=O)[CH:28]([OH:35])[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34]>>[OH:1][CH:2]([CH2:21][OH:22])[CH2:3][N:4]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[C:27](=[O:26])[CH:28]([OH:35])[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34]

参加物

4

反応物 3

HCID 14797Potassium HydroxideHCID 1110073-(Hexadecylamino)propane-1,2-diolHCID 10487462Methyl 2-hydroxyoctanoate

生成物 1

HCID 10217103N-(2,3-dihydroxypropyl)-N-hexadecyl-2-hydroxyoctanamide

実験手順

N-(2,3-dihydroxypropyl)-N-hexadecylamine (1.0 g, 0.0032 mole) and potassium hydroxide (0.01 g, 0.18 mmole) were heated to 85° C. under vacuum and methyl-2-hydroxyoctanoate (0.55 g, 0.0032 mole) was heated and added dropwise to the reaction. The reaction was heated under vacuum for 6 hours. A waxy off-white solid was obtained (crude yield=1.39 g). The waxy solid was recrystalized from hot hexane (yield=0.88 g).

後処理

  1. temperaturewas heated
  2. additionadded dropwise to the reaction
  3. temperatureThe reaction was heated under vacuum for 6 hours
  4. customA waxy off-white solid was obtained (crude yield=1.39 g)
  5. customThe waxy solid was recrystalized from hot hexane (yield=0.88 g)

出典と根拠

ORDレコード
ord-55edb80f6cc242c1b9188db1b41de0c4
出典データセット
uspto-grants-1995_12
特許番号
US05476671

反応ノート

読み込み中…