反应详情

To a solution of isophtalaldehyde (8 g) in ethanol (80 mL) at room temperature was added NaBH4 portion wise, until about 50% reaction by TLC. The reaction mixture was quenched with 25% ammonium acetate, extracted with ethyl acetate, which was washed with brine (2×), dried over sodium sulfate, filtered and evaporated to dryness. Purification of the residue by flash chromatography using 50% ether in hexane afforded the pure title compound.

1. customuntil about 50% reaction by TLC
2. customThe reaction mixture was quenched with 25% ammonium acetate
3. extractionextracted with ethyl acetate, which
4. washwas washed with brine (2×)
5. dry with materialdried over sodium sulfate
6. filtrationfiltered
7. customevaporated to dryness
8. customPurification of the residue by flash chromatography