Vinyl Acetate → HCID 54446963, compound

Participants

Reaction Steps

To a solution of 2-naphthyl triflate (90 g, 326 mmol) in DMF (240 ml), add triphenylphosphine (9.6 g, 36.6 mmol), vinyl acetate (149 g, 1862 mmol) and palladium acetate (3.8 g, 17 mmol). Reflux the reaction mixture for 1 h, then quench by addition of sat'd NaHCO3 solution. Extract the mixture with Et2O, dry and concentrate. Purify the residue by chromatography on silica gel (5% EtOAc in hexane) to obtain 35 g (165 mmol, 51%) 2-(2-naphthyl)vinyl acetate.

Provenance & Evidence