Benzene → HCID 15196530, compound

Participants

Reaction Steps

NH2 --(R)--CH(C2H5)C(CH3)3 : To a cooled solution (0°) of 4,4-dimethyl-3-pentanone (106 g, 0.928 mol), triethylamine (513 mL, 3.68 mol), and (R)-δ-methylbenzylamine (114 g, 0.940 mol) in dry benzene (1 L), a solution of TiCl4 (50.5 mL, 0,459 mol) in benzene (200 mL) was added at a rate that kept the temperature of the mixture below 10°. Thereafter, the mixture was stirred mechanically for 3 h at 40°, cooled to room temperature and filtered through diatomaceous earth. The diatomaceous earth was washed with Et2O. The combined filtrate and wash was concentrated. The residue was dissolved in dry MeOH (2 L). The solution was cooled to 0° and NaBH4 (20 g, 0.53 mol) was added portionwise while maintaining the temperature of the mixture below 5°. Approximately 2 mL of 10% aqueous HCl was added and the MeOH was evaporated. The residue was dissolved in Et2O. The solution was washed with brine, dried (MgSO4) and evaporated to dryness to give a reddish oil (a 18:1 mixture of diastereoisomers as indicated by NMR). The oil was purified by flash chromatography (SiO2, eluent: EtOAc/hexane, 7:93) to afford N-(1(R)-phenylethyl)-1(R)-ethyl-2,2-dimethylpropylamine as a liquid (110 g, 54%). This material was dissolved in hexane (1.5 L). 6N HCl in dioxane (90 mL) was added to the solution over a period of 15 min. The resulting white solid was collected on a filter and then washed with hexane to provide N-(1(R)-phenylethyl)-1(R)-ethyl-2,2-dimethylpropyl hydrochloride (125 g, 97%). 1H NMR(CDCl3) δ0.55 (t, J=7.5 Hz, 3H), 1.14 (s, 9H), 1.54-1.95 (m, 2H), 2.23 (d, J=6.5 Hz, 3H), 2.36-2.44 (m, 1H), 4.31-4.49 (m, 1H), 7.30-7.48 (m, 3H), 7.74-7.79 (m, 2H).

Provenance & Evidence