反应详情

Selenium oxide (6.88%) is heated to dissolve in 100 ml aqueous dioxane (95:5 dioxane: H2O). The 2-acetyl-5-chlorothiophene (5.00 g) is added to the mixture. The resulting mixture is refluxed overnight, then cooled. The precipitated selenium metal is filtered after solvent removal a brown thick oil results which solidifies on standing. The solid is heated to dissolve in 400 ml hot water, filtered and allowed to cool to room temperature. The precipitate is collected by filtration, washed with fresh H2O and dried to obtain a light brown flake. The second crop is obtained by extracting the mother liquid with ethylacetate, separated, dried (MgSO4) and concentrated in vacuo to give a light yellow solid which upon treatment with HPLC gives 2-chloro-5-glyoxyloylthiophene, which is used directly in the next step.

1. temperatureThe resulting mixture is refluxed overnight
2. temperaturecooled
3. filtrationThe precipitated selenium metal is filtered
4. customafter solvent removal a brown thick oil
5. customresults which
6. temperatureThe solid is heated
7. filtrationfiltered
8. filtrationThe precipitate is collected by filtration
9. washwashed with fresh H2O
10. customdried
11. customto obtain a light brown flake
12. customThe second crop is obtained
13. extractionby extracting the mother liquid with ethylacetate
14. customseparated
15. dry with materialdried (MgSO4)
16. concentrationconcentrated in vacuo
17. customto give a light yellow solid which upon treatment with HPLC