1-(3-Fluoro-4-methoxyphenyl)ethan-1-one → 3-Fluoro-4-methoxy-alpha-oxobenzeneacetaldehyde

Participants

Reaction Steps

Selenium oxide (4.953 g) is heated to dissolve in 100 ml aqueous dioxane (95:5 dioxane: H2O). The 3-fluoro-4-methoxyacetophenone (5.00 g) is added to the mixture. The resulting mixture is refluxed overnight then coiled. The precipitated selenium metal is filtered. The filtrate is concentrated in vacuo to give a brown thick gum. It is recrystallized from -~200 ml hot H2O, filtered hot and allowed to stand at RT overnight. The precipitated pale pink flake are filtered, washed with H2O and let air dried to give 1-methoxy-2-fluoro-4-glyoxyloylbenzene, which is used directly in the next step.

Provenance & Evidence