Water → HCID 18999800, compound

Participants

Reaction Steps

To an ice-colded suspension of NaH (0.029 g) in 30 ml of anhydrous THF under N2 is added 7-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-g]quinoxaline (0.30 g). The orange-red mixture is stirred at the same temperature for 5 minutes, then acetic anhydride (0.122 g) is added dropwise to the mixture. A yellow solid forms during the acetic anhydride additions. The resulting mixture is stirred at room temperature overnight. The mixture is poured into water. The yellow solid is filtered, washed with water then with ether and dried. The product is purified by column chromatography eluting with 15% ethylacetate in hexane, 25% ethylacetate in hexane then 5% ethylacetate in methylene chloride to obtain 1-acetyl-7-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-g]quinoxaline (m.p. 261°-265° C.) and 1-acetyl-7-(3-fluoro-4-methoxyphenyl)-2H-pyrazolo[3,4-g]quinoxaline.

Provenance & Evidence