Water → HCID 18999834, compound

Participants

Reaction Steps

NaH (60%; 0.35 g) is added into a stirring solution of 2.14 g of 7-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-g]quinoxaline in 30 ml of anhydrous DMF and stirred for 15 minutes, then 1.34 g of 2-bromoethylacetate is added into the mixture slowly. The resulting mixture is stirred at room temperature for 21/2 hours then poured into water and the product is filtered off, washed with water and dried. This is purified by column chromatography using 5% →20% ethylacetate in methylene chloride as eluent to obtain 1-(2-acetoxyethyl)-7-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-g]quinoxaline (m.p. 164°-166° C.) and 2-(2-acetoxyethyl)-7-(3-fluoro-4-methoxyphenyl)-2H-pyrazolo[3,4-g]quinoxaline (m.p. 175°-178° C.).

Provenance & Evidence