Sodium Hydroxide → HCID 10379653, compound

HRID 2260128Notes

Reaction equation

HRID 2260128 reaction equation
[C:1]1([CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][CH:12]([C:15]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)(C3SC=CC=3)[OH:16])[CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1(C(C2CCN(CCC3C=CC=CC=3)CC2)=O)C=CC=CC=1.Cl.[OH-].[Na+]>C(Cl)Cl>[C:22]1([C:15]([CH:12]2[CH2:13][CH2:14][N:9]([CH2:8][CH2:7][C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[CH2:10][CH2:11]2)=[O:16])[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 14257839HCID 14257839, compoundHCID 18930354HCID 18930354, compound

Product 1

HCID 10379653HCID 10379653, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

α-[1-(2-phenylethyl)-4-piperidinyl]-α-phenyl-2-thiophenemethanol ##STR66## Mix phenyl[1-(2-phenylethyl)-4-piperidinyl]methanone·HCl (5.0 g, 15.16 mmol), 1N sodium hydroxide (100 mL) and methylene chloride (250 mL) and stir overnight at room temperature. Separate the organic phase and extract the aqueous phase with methylene chloride. Combine the organic phases, dry (MgSO4) and evaporate the solvent in vacuo to give phenyl[1-(2-phenylethyl)-4-piperidinyl]methanone.

Workup

  1. customSeparate the organic phase
  2. extractionextract the aqueous phase with methylene chloride
  3. dry with materialdry (MgSO4)
  4. customevaporate the solvent in vacuo

Sources & evidence

ORD record
ord-1e5ce28aa70a48489edfb1fcdb72442d
Source dataset
uspto-grants-1995_12
Patent number
US05476861

Reaction notes

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