HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(1-Propenyl)-4-(4-fluorophenoxy)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-(4-Fluorophenoxy)-2-(prop-2-en-1-yl)phenol | HCID 18672473 | — |
| Solvent | Potassium hydroxide ethanol | HCID 21946426 | — |
| Product | 2-(1-Propenyl)-4-(4-fluorophenoxy)phenol | HCID 54379250 | — |
Reaction Steps
A solution of 2-allyl-4-(4-fluorophenoxy)phenol, from above, in saturated KOH/ethanol (65 mls) was refluxed for 18 hrs. It was then cooled to r.t. and acidified to pH2 by that addition of 10% HCl. The aqueous solution was then extracted with ethylacetate (3×200 mls). The organics were combined, dried with MgSO4 and concentrated to afford 17.52 g of 2-(1-propenyl)-4-(4-fluorophenoxy)phenol as a brownish oil which was used as is.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05476873 |
| Source dataset | uspto-grants-1995_12 |
| ORD ID | ord-55d3ec80d3c8429f8c3f95d8674790c5 |
| Source note | uspto-grants-1995_12 |