Sodium Acetate → HCID 21459119, compound

HRID 2260247Notes

Reaction equation

HRID 2260247 reaction equation
[C:1]([O-:4])(=[O:3])[CH3:2].[Na+].Br[CH2:7][C:8]([C:10]1[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[C:13]([OH:19])=[C:12]([OH:20])[CH:11]=1)=[O:9]>>[C:1]([O:4][CH2:7][C:8](=[O:9])[C:10]1[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[C:13]([OH:19])=[C:12]([OH:20])[CH:11]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 517045Sodium AcetateHCID 218455962-Bromo-1-(3,4-dihydroxy-5-nitro-phenyl)-ethanone

Product 1

HCID 21459119HCID 21459119, compound

Procedure

1.26 g of sodium acetate are added to a solution of 1.35 g of 2-bromo-3',4'-dihydroxy-5'-nitroacetophenone in 25 ml of alcohol and heated to boiling under reflux. After 6 hours, the reaction mixture is filtered from separated sodium bromide and evaporated. The residue is dissolved in ethyl acetate. The solution is washed with saturated sodium chloride solution, dried over sodium sulfate, filtered and evaporated at 50°. There is obtained (3,4-dihydroxy-5-nitrobenzoyl)methyl acetate of m.p. 166°-168° (from ethyl acetate/ether).

Workup

  1. temperatureheated
  2. temperatureunder reflux
  3. filtrationthe reaction mixture is filtered
  4. customfrom separated sodium bromide
  5. customevaporated
  6. dissolutionThe residue is dissolved in ethyl acetate
  7. washThe solution is washed with saturated sodium chloride solution
  8. dry with materialdried over sodium sulfate
  9. filtrationfiltered
  10. customevaporated at 50°

Sources & evidence

ORD record
ord-168fa394182f40759261bdf232e08970
Source dataset
uspto-grants-1995_12
Patent number
US05476875

Reaction notes

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