Sodium Hydroxide → (2-Fluoro-3,4-dimethoxyphenyl)methanol

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Reaction Steps

5.4 g of 2-fluoro-3,4-dimethoxybenzyl acetate are heated to 80° for 1.5 hours together with 50 ml of methanol and 50 ml of 1N sodium hydroxide solution. After evaporation of the methanol the residue is extracted with methylene chloride. The combined extracts are washed with water, dried over sodium sulfate and evaporated. The residue is chromatographed on 80 g of silica gel with methylene chloride/methanol (95:5), 2-fluoro-3,4-dimethoxybenzyl alcohol is obtained as an oil.

Provenance & Evidence