反应详情

Using a procedure analogous to Example 17A, 2,2-dimethyl-N-(6-methyl-pyridazin-3-yl)-propionamide (4.18 g, 21.65 mmol) and 3.0 M solution of EtMgBr (36 mL, 108.29 mmol) give the title compound (0.83 g, 3.76 mmol, 17%). 1H NMR (CDCl3): δ 1.24 (t, J=7.5 Hz, 3H), 1.37 (s, 9H), 2.62 (q, J=7.5 Hz, 2H), 2.66 (s, 3H), 7.23 (s, 1H), 8.50 (s, 1H) ppm. ES-MS (m/z): calcd for C12H19N3O (M+H)+: 222.3. found: 222.1.