8-(1-Ethyl-propyl)-3-iodo-2,6-dimethyl-imidazo[1,2-b]pyridazine → HCID 57752658, compound

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Reaction Steps

Using a procedure analogous to Example 16B, 8-ethyl-2,6-dimethyl-imidazo[1,2-b]pyridazine (0.30 g, 1.71 mmol) and 8-(1-ethyl-propyl)-3-iodo-2,6-dimethyl-imidazo[1,2-b]pyridazine (0.59 g, 1.71 mmol) give the title compound (0.25 g, 0.64 mmol, 38%). 1H NMR (CDCl3): δ 0.90 (t, J=7.5 Hz, 6H), 1.43 (d, J=1.4 Hz, 3H), 1.78-1.92 (m, 4H), 2.42 (s, 3H), 2.43 (s, 3H), 2.44 (s, 3H), 2.45 (s, 3H), 3.11 (q, J=7.5 Hz, 2H), 3.34-3.42 (m, 1H), 6.67 (s, 1H), 6.74 (s, 1H) ppm. ES-MS (m/z): calcd for C23H30N6 (M+H)+: 391.5. found: 391.3.

Provenance & Evidence