HCID 14450975, compound → HCID 14450976, compound

HRID 2260314Notes

Reaction equation

HRID 2260314 reaction equation
[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1.[CH2:12]([O:19][C:20]1[CH:34]=[CH:33][C:23]([CH:24]([OH:32])[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[F:31])=[CH:22][C:21]=1[O:35][CH3:36])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH2:12]([O:19][C:20]1[CH:34]=[CH:33][C:23]([C:24]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[F:31])=[O:32])=[CH:22][C:21]=1[O:35][CH3:36])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 14450975HCID 14450975, compoundHCID 178418287HCID 178418287, compound

Product 1

HCID 14450976HCID 14450976, compound

Procedure

69.8 g of 4-(benzyloxy)-2'-fluoro-3-methoxybenzhydrol (dissolved in 600 ml of methylene chloride) are treated within 30 minutes at 20° with 45.3 g of pyridinium chlorochromate and stirred at 20° for 3 hours. The precipitate formed is subsequently filtered and washed with methylene chloride. The filtrate is evaporated and the residue is filtered on 100 g of silica gel with ether. After recrystallization from ether, there is obtained 4-(benzyloxy)-2'-fluoro-3-methoxybenzophenone of m.p. 118°-120°.

Workup

  1. customThe precipitate formed
  2. filtrationis subsequently filtered
  3. washwashed with methylene chloride
  4. customThe filtrate is evaporated
  5. filtrationthe residue is filtered on 100 g of silica gel with ether
  6. customAfter recrystallization from ether

Sources & evidence

ORD record
ord-4804e21518264cfd8f7b9a5fb5967f43
Source dataset
uspto-grants-1995_12
Patent number
US05476875

Reaction notes

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