HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Phenylethyl)thiourea → 3-Nitro-5-[2-(phenethylamino)-4-thiazolyl]pyrocatechol hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Phenylethyl)thiourea | HCID 735845 | — |
| Reactant | 2-Bromo-1-(3,4-dihydroxy-5-nitro-phenyl)-ethanone | HCID 21845596 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 3-Nitro-5-[2-(phenethylamino)-4-thiazolyl]pyrocatechol hydrobromide | HCID 21459205 | — |
Reaction Steps
A suspension of 13.8 g of 2-bromo-3',4'-dihydroxy-5'-nitroacetophenone is treated with 9.0 g of 1-(phenethyl)-2-thiourea in 150 ml of n-butanol and the mixture is heated to boiling under reflux for 3 hours. After cooling to room temperature, the crystals are filtered under suction and crystallized from n-butanol. There is obtained 3-nitro-5-[2-(phenethylamino)-4-thiazolyl]pyrocatechol hydrobromide of m.p. 249°-251°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05476875 |
| Source dataset | uspto-grants-1995_12 |
| ORD ID | ord-99169862494842a1bcf5b6ec23869639 |
| Source note | uspto-grants-1995_12 |