反应详情

3,5-Bis(1,1-dimethylethyl)benzenethiol (0.0078 mole) and the title compound of Example 18 (0.0074 mole) are added to a degassed (Argon) solution of 50% sodium hydroxide (5 ml) and isopropyl alcohol (50 ml). The reaction is heated to reflux for 24 hours. The reaction is cooled to room temperature and poured into water (125 ml). The solution is made acidic with 1N hydrochloric acid and extracted 3 times with 100 ml of diethyl ether. The combined diethyl ether extracts are dried over anhydrous magnesium sulfate, filtered and concentrated with a rotary evaporator. The product is purified by silica gel chromatography.

1. customa degassed (Argon) solution of 50% sodium hydroxide (5 ml) and isopropyl alcohol (50 ml)
2. temperatureThe reaction is heated
3. temperatureto reflux for 24 hours
4. additionpoured into water (125 ml)
5. extractionextracted 3 times with 100 ml of diethyl ether
6. dry with materialThe combined diethyl ether extracts are dried over anhydrous magnesium sulfate
7. filtrationfiltered
8. concentrationconcentrated with a rotary evaporator
9. customThe product is purified by silica gel chromatography