8-(1-Ethyl-propyl)-3-iodo-2,6-dimethyl-imidazo[1,2-b]pyridazine → HCID 57752615, compound

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Reaction Steps

Using a procedure analogous to Example 16B, 8-cyclopentyl-2,6-dimethyl-imidazo[1,2-b]pyridazine (0.41, 1.86 mmol) and 8-(1-ethyl-propyl)-3-iodo-2,6-dimethyl-imidazo[1,2-b]pyridazine (0.63 g, 1.86 mmol) give the title compound (0.43 g, 1.0 mmol, 54%). 1H NMR (CDCl3): δ 0.92 (t, J=7.4 Hz, 6H), 1.70-1.96 (m, 10H), 2.25-2.35 (m, 2H), 2.43 (s, 3H), 2.44 (s, 3H), 2.47 (s, 6H), 3.35-3.48 (m, 1H), 3.78-3.90 (m, 1H), 6.68 (s, 1H), 6.76 (s, 1H) ppm. ES-MS (m/z): calcd for C26H34N6 (M+H)+: 431.6. found: 431.3.

Provenance & Evidence