2-(2-Aminoethylamino)-5-nitropyridine → HCID 53817346, compound

HRID 2260431Notes

Reaction equation

HRID 2260431 reaction equation
[NH2:1][CH2:2][CH2:3][NH:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][N:6]=1.[CH3:14][C:15]([C:18]1[CH:19]=[C:20]([S:28][C@@H:29]2[CH2:34][CH2:33][CH2:32][CH2:31][C@H:30]2[S:35][CH2:36][C:37](N(C)CCC2C=CC=CN=2)=[O:38])[CH:21]=[C:22]([C:24]([CH3:27])([CH3:26])[CH3:25])[CH:23]=1)([CH3:17])[CH3:16]>>[CH3:27][C:24]([C:22]1[CH:21]=[C:20]([S:28][C@@H:29]2[CH2:34][CH2:33][CH2:32][CH2:31][C@H:30]2[S:35][CH2:36][C:37]([NH:1][CH2:2][CH2:3][NH:4][C:5]2[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][N:6]=2)=[O:38])[CH:19]=[C:18]([C:15]([CH3:14])([CH3:16])[CH3:17])[CH:23]=1)([CH3:25])[CH3:26]

Participants

3

Reactant 2

HCID 1224252-(2-Aminoethylamino)-5-nitropyridineHCID 15287679HCID 15287679, compound

Product 1

HCID 53817346HCID 53817346, compound

Procedure

Substituting 2-(2-aminoethylamino)-5-nitropyridine for the 2-(2-methylaminoethyl)pyridine of Example 16, and following the procedure described therein, gives trans-2-[[2-[[3,5-bis(1,1-dimethylethyl)phenyl]thio]cyclohexyl]thio]-N-[[(5-nitropyridin-2-yl)amino]ethyl]acetamide.

Sources & evidence

ORD record
ord-cfb7afbeb3cc41539b6658347857a240
Source dataset
uspto-grants-1995_12
Patent number
US05476944

Reaction notes

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