2-(2-Aminoethyl)-1-methylpyrrolidine → HCID 54363031, compound

HRID 2260432Notes

Reaction equation

HRID 2260432 reaction equation
NCCC1CCCN1C.[CH3:10][C:11]([C:14]1[CH:15]=[C:16]([S:24][C@@H:25]2[CH2:30][CH2:29][CH2:28][CH2:27][C@H:26]2[S:31][CH2:32][C:33]([N:35](C)[CH2:36][CH2:37][C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][N:39]=2)=[O:34])[CH:17]=[C:18]([C:20]([CH3:23])([CH3:22])[CH3:21])[CH:19]=1)([CH3:13])[CH3:12]>>[CH3:10][C:11]([C:14]1[CH:15]=[C:16]([S:24][C@@H:25]2[CH2:30][CH2:29][CH2:28][CH2:27][C@H:26]2[S:31][CH2:32][C:33]([NH:35][CH2:36][CH2:37][CH:38]2[CH2:43][CH2:42][CH2:41][N:39]2[CH3:40])=[O:34])[CH:17]=[C:18]([C:20]([CH3:23])([CH3:22])[CH3:21])[CH:19]=1)([CH3:13])[CH3:12]

Participants

3

Reactant 2

HCID 983882-(2-Aminoethyl)-1-methylpyrrolidineHCID 15287679HCID 15287679, compound

Product 1

HCID 54363031HCID 54363031, compound

Procedure

Substituting 2-(2-aminoethyl)-1-methylpyrrolidine for the 2-(2-methylaminoethyl)pyridine of Example 16, and following the procedure described therein, gives trans-2-[[2-[[3,5-bis(1,1-dimethylethyl)phenyl]thio]cyclohexyl]thio]-N-[(1-methylpyrrolidin-2-yl)ethyl]acetamide.

Sources & evidence

ORD record
ord-dc37479650fd47a782c76593958cf1a9
Source dataset
uspto-grants-1995_12
Patent number
US05476944

Reaction notes

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