3-Pyridinemethanamine → HCID 53990926, compound

HRID 2260435Notes

Reaction equation

[NH2:1][CH2:2][C:3]1[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=1.[CH3:9][C:10]([C:13]1[CH:14]=[C:15]([S:23][C@@H:24]2[CH2:29][CH2:28][CH2:27][CH2:26][C@H:25]2[S:30][CH2:31][C:32](N(C)CCC2C=CC=CN=2)=[O:33])[CH:16]=[C:17]([C:19]([CH3:22])([CH3:21])[CH3:20])[CH:18]=1)([CH3:12])[CH3:11]>>[CH3:22][C:19]([C:17]1[CH:16]=[C:15]([S:23][C@@H:24]2[CH2:29][CH2:28][CH2:27][CH2:26][C@H:25]2[S:30][CH2:31][C:32]([NH:1][CH2:2][C:3]2[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=2)=[O:33])[CH:14]=[C:13]([C:10]([CH3:9])([CH3:11])[CH3:12])[CH:18]=1)([CH3:20])[CH3:21]

Participants

Reactant 2

HCID 310183-Pyridinemethanamine

HCID 15287679HCID 15287679, compound

Product 1

HCID 53990926HCID 53990926, compound

Procedure

Substituting 3-(aminomethyl)pyridine for the 2-(2-methylaminoethyl)pyridine of Example 16, and following the procedure described therein, gives trans-2-[[2-[[3,5-bis(1,1-dimethylethyl)phenyl]thio]cyclohexyl]thio]-N-(3-pyridinylmethyl)-acetamide.

Sources & evidence

ORD record: ord-3a771fd8f01b44b88387796e51b88088
Source dataset: uspto-grants-1995_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05476944

Reaction notes

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