(6-Methylpyridin-2-yl)methanamine → HCID 54251916, compound

HRID 2260437Notes

Reaction equation

HRID 2260437 reaction equation
[NH2:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[N:4]=1.[CH3:10][C:11]([C:14]1[CH:15]=[C:16]([S:24][C@@H:25]2[CH2:30][CH2:29][CH2:28][CH2:27][C@H:26]2[S:31][CH2:32][C:33](N(C)CCC2C=CC=CN=2)=[O:34])[CH:17]=[C:18]([C:20]([CH3:23])([CH3:22])[CH3:21])[CH:19]=1)([CH3:13])[CH3:12]>>[CH3:23][C:20]([C:18]1[CH:17]=[C:16]([S:24][C@@H:25]2[CH2:30][CH2:29][CH2:28][CH2:27][C@H:26]2[S:31][CH2:32][C:33]([NH:1][CH2:2][C:3]2[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[N:4]=2)=[O:34])[CH:15]=[C:14]([C:11]([CH3:10])([CH3:12])[CH3:13])[CH:19]=1)([CH3:21])[CH3:22]

Participants

3

Reactant 2

HCID 246721(6-Methylpyridin-2-yl)methanamineHCID 15287679HCID 15287679, compound

Product 1

HCID 54251916HCID 54251916, compound

Procedure

Substituting 2-aminomethyl-6-methylpyridine for the 2-(2-methylaminoethyl)pyridine of Example 16, and following the procedure described therein, gives trans-2-[[2-[[3,5-bis(1,1-dimethylethyl)phenyl]thio]cyclohexyl]thio]-N-[(6-methylpyridine-2-yl)methyl]acetamide. ##STR99##

Sources & evidence

ORD record
ord-844a1411baf842b7a0ca95410308dee0
Source dataset
uspto-grants-1995_12
Patent number
US05476944

Reaction notes

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