関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Chloro-2-nitrobenzene | HCID 6945 | — |
| 反応物 | O-Xylene | HCID 7237 | — |
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | 4-Methylpentane-1,2-diol | HCID 91171 | — |
| 反応物 | Potassium Fluoride | HCID 522689 | — |
| 触媒 | Tetramethylammonium chloride | HCID 6379 | — |
| 生成物 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
反応手順
In a 2-liter flange flask fitted with a distillation bridge and impeller stirrer, 290.5 g (5.0 mol) of potassium fluoride, 71.1 g (0.1 mol) of trimethyl (ethoxypolyoxypropyl) ammonium chloride, 11.0 g (0.1 mol) of tetramethylammonium chloride and 17.7 g (0.035 mol) of polyethylene glycol dimethyl ether 500 were introduced at 120° C. into the melt of 630 g (4.0 mol) of 2-chloronitrobenzene. Subsequently, 100 g (0.38 mol) of xylene were added and the reaction mixture was stirred for 21 hours at a temperature of 150° C. Amount of 2-fluoronitrobenzene formed, according to GC analysis:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05476976 |
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| 出典データセット | uspto-grants-1995_12 |
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| ORD ID | ord-465347a2c41342d48226a5bbf0083f9d |
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| 出典メモ | uspto-grants-1995_12 |
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